Effects of Systemic Anticancer Treatment on Cardiorespiratory Fitness
Sara Hassing Johansen, Torbjørn Wisløff, Elisabeth Edvardsen, Sofie T Kollerud, Julio Jensen, Ginika Agwu, Konstantina Matsoukas, Jessica M. Scott, Tormod S. Nilsen
Abstract
BACKGROUND: Poor cardiorespiratory fitness (CRF) is associated with a higher symptom burden and an increased prevalence of long-term treatment-related cardiovascular disease risk factors in cancer survivors. However, the magnitude of systemic therapy-related CRF impairment remains unclear. OBJECTIVES: The aim of this study was to evaluate the effects of systemic anticancer treatment on CRF and identify physiological determinants underpinning CRF impairment. METHODS: . Two meta-regressions were conducted to examine the association between CRF and cardiac output and arteriovenous oxygen difference. RESULTS: (β = 2.55; 95% CI: 2.05-3.06; P < 0.001). CONCLUSIONS: Systemic anticancer treatment leads to substantial and sustained impairments in CRF.