Prodromal neuroinflammatory, cholinergic and metabolite dysfunction detected by PET and MRS in the TgF344-AD transgenic rat model of AD: a collaborative multi-modal study
Aisling M. Chaney, Francisco R. Lopez‐Picon, Sophie Sérrière, Rui Wang, Daniela Bochicchio, Samuel David Webb, Matthias Vandesquille, Michael Harte, Christina Georgiadou, Catherine B. Lawrence, Julie Busson, Johnny Vercouillie, Clovis Tauber, Frédéric Buron, Sylvain Routier, Tristan A. Reekie, Anniina Snellman, Michael Kassiou, Johanna Rokka, Karen Davies, Juha O. Rinne, Derviş A. Salih, Frances A. Edwards, Llwyd Orton, S. R. Williams, Sylvie Chalon, Hervé Boutin
Abstract
techniques, and is a useful model to assess and longitudinally monitor early neurotransmission dysfunction and neuroinflammation in AD.
Topics & Concepts
NeuroinflammationGenetically modified mouseImmunohistochemistryCholinergicNeurosciencePathologyWestern blotChemistryPsychologyMedicineTransgeneDiseaseBiochemistryGeneAlzheimer's disease research and treatmentsTryptophan and brain disordersNeuroscience and Neuropharmacology Research