Correlation Between Immunoglobulin Dose Administered and Plasma Neutralization of Streptococcal Superantigens in Patients With Necrotizing Soft Tissue Infections
Helena Bergsten, Martin Bruun Madsen, François Bergey, Ole Hyldegaard, Steinar Skrede, Per Arnell, Oddvar Oppegaard, Andreas Itzek, Anders Perner, Mattias Svensson, Anna Norrby‐Teglund, INFECT Study Group, Michael Nekludov, Anders Kjellberg, Trond Bruun, Torbjørn Nedrebø, Dag Harald Skutlaberg, Anshu Babbar, Anders Rosén, Vítor A. P. Martins dos Santos, Michael Nekludov, Anders Kjellberg, Trond Bruun, Torbjørn Nedrebø, Dag Harald Skutlaberg, Anshu Babbar, Anders Rosén, Vítor A. P. Martins dos Santos
Abstract
Analyses of plasma collected pre- and postadministration of intravenous immunoglobulin (IVIG) from patients with group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r = -.67, P < .0001). One 25-g IVIG dose was sufficient to yield plasma-neutralizing activity against streptococcal superantigens. Clinical Trials Registration. NCT01790698 and NCT02111161.