Litcius/Paper detail

Homozygosity for R47H in <i>TREM2</i> and the Risk of Alzheimer’s Disease

Hreinn Stefánsson, G. Bragi Walters, Garðar Sveinbjörnsson, Vinicius Tragante, Gudmundur Einarsson, Hannes Helgason, Asgeir Sigurðsson, Doruk Beyter, Audunn S Snaebjarnarson, Erna V. Ivarsdottir, Gudmar Thorleifsson, Bjarni V. Halldórsson, Gudmundur Norddahl, Unnur Styrkársdóttir, Árni Sturluson, Hilma Holm, Agnar Helgason, Kristjan H. S. Moore, Hannes P. Eggertsson, Ásmundur Oddsson, Gudrun A Jonsdottir, Arni F Gunnarsson, Gyða Björnsdóttir, Rósa S. Gísladóttir, Thorgeir E. Thorgeirsson, Ástrós Skúladóttir, Daníel F. Guðbjartsson, Patrick Sulem, Pálmi V. Jónsson, Steinunn Þórðardóttir, Jón Snædal, Helga Eyjolfsdottir, Byron Creese, Clive Ballard, Anne Corbett, Miguel Vasconcelos Da Silva, Dag Aarsland, Ole A Andreassen, Geir Selbæk, Srdjan Djurovic, Eystein Stordal, Thormod Fladby, Jan Haavik, Jannicke Igland, Lasse M Giil, Sture Eriksson, Göran Hallmans, Hugo Lövheim, Karin Lopatko Lindman, Miles Trupp, Lars Forsgren, Thomas Werge, Karina Banasik, Søren Brunak, Henrik Ullum, Ruth Frikke-Schmidt, Sisse Rye Ostrowski, Maria Didriksen, Erik Sørensen, Anja H Simonsen, Jørgen E Nielsen, Gunhild Waldemar, Ole B Pedersen, Christian Erikstrup, Kirk U. Knowlton, Lincoln Nadauld, Kari Stefansson

2024New England Journal of Medicine13 citationsDOI

Abstract

A meta-analysis of tests of association between variants in TREM2 and Alzheimer's disease showed high risk among R47H homozygotes.

Topics & Concepts

TREM2DiseaseAlzheimer's diseaseMedicineInternal medicineMicrogliaInflammationInflammation biomarkers and pathwaysNeuroinflammation and Neurodegeneration MechanismsImmune Response and Inflammation