SGLT2 inhibitors for genetic and acquired insulin resistance: Considerations for clinical use
Yusei Hosokawa, Wataru Ogawa
Abstract
Administration of an sodium-glucose cotransporter 2 inhibitor to individuals with insulin resistance reduces the level of glucose disposal necessary to maintain glycemia as a result of the induced increase in urinary glucose excretion. The amount of insulin required for a certain level of glucose disposal, on which the evaluation of insulin resistance is usually based, might thus decrease even without amelioration of insulin resistance.
Topics & Concepts
MedicineInsulin resistanceDiabetes mellitusBioinformaticsIntensive care medicinePharmacologyComputational biologyEndocrinologyBiologyDiabetes Treatment and ManagementPancreatic function and diabetesDiabetes Management and Research