Establishing the selective phospholipid membrane coordination, permeation and lysis properties for a series of ‘druggable’ supramolecular self-associating antimicrobial amphiphiles
Jessica E. Boles, C. Richard Bennett, Jennifer L. Baker, Kira L. F. Hilton, Hiral A. Kotak, Ewan R. Clark, Yifan Long, Lisa J. White, Hin Yuk Lai, Charlotte K. Hind, J. Mark Sutton, Michelle D. Garrett, Anne Cheasty, Jose L. Ortega‐Roldan, Mark Charles, Cally J. E. Haynes, Jennifer R. Hiscock
Abstract
A combination of computational and synthetic phospholipid vesicle/nanodisc assays are used to investigate the mode of action for a class of antimicrobial agents, while a range of DMPK studies establish agent druggability.
Topics & Concepts
DruggabilityAmphiphileSupramolecular chemistryChemistryPhospholipidAntimicrobialLysisMembraneCombinatorial chemistryBiochemistryOrganic chemistryCopolymerMoleculePolymerGeneMolecular Sensors and Ion DetectionLipid Membrane Structure and BehaviorSupramolecular Self-Assembly in Materials