Mitochondrial mutations in protein coding genes of respiratory chain including complexes IV, V, and mt-tRNA genes are associated risk factors for congenital heart disease
Mohammad Heidari, Mehri Khatami, Akram Kamalipour, M Eslami Kalantari, Mahsa Movahed, Mohammad Hayet Emmamy, Mehdi Hadadzadeh, José Bragança, Mohsen Namnabat, Bahareh Mazrouei
Abstract
and predicted to convey a predisposing risk factor for CHD. Further studies are necessary to better understand the mechanisms by which the alterations identified in the present study contribute to the development of CHD in patients.
Topics & Concepts
Mitochondrial DNABiologyGeneticsGeneMitochondrionMissense mutationRespiratory chainTransfer RNAMitochondrial respiratory chainMitochondrial diseaseSilent mutationGenomeMutationMolecular biologyRNAMitochondrial Function and PathologyRNA modifications and cancerCongenital Heart Disease Studies