Discovery of novel verinurad analogs as dual inhibitors of URAT1 and GLUT9 with improved Druggability for the treatment of hyperuricemia
Zean Zhao, Jin Liu, Peihua Kuang, Jian Luo, Goverdhan Surineni, Xiaolin Cen, Ting Wu, Ying Cao, Pingzheng Zhou, Jianxin Pang, Qun Zhang, Jianjun Chen
Topics & Concepts
ChemistryPharmacologyIC50HyperuricemiaBioavailabilityIn vivoPharmacokineticsUricosuricIn vitroBiochemistryUric acidBiologyBiotechnologyGout, Hyperuricemia, Uric AcidIon Transport and Channel RegulationBiochemical and Molecular Research