A CRISPR activation screen identifies FBXO22 supporting targeted protein degradation
Ananya A. Basu, Chenlu Zhang, Isabella A. Riha, Assa Magassa, Miguel Campos, Alana Caldwell, Felicia Ko, Xiaoyu Zhang
Topics & Concepts
CRISPRUbiquitin ligaseProtein degradationUbiquitinSkp1BiologyUbiquitin-Protein LigasesNeddylationComputational biologyBromodomainDegronCell biologyGeneGeneticsHistoneProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysPeptidase Inhibition and Analysis