Discovery of novel coumarin-indole derivatives as tubulin polymerization inhibitors with potent anti-gastric cancer activities
Jian Song, Yong-Feng Guan, Wen‐Bo Liu, Chun-Hong Song, Xin-Yi Tian, Ting Zhu, Xiang-Jing Fu, Ying-Qiu Qi, Sai‐Yang Zhang
Topics & Concepts
ChemistryMAPK/ERK pathwayTubulinCancer cellKinaseMicrotubule polymerizationCancerCell growthApoptosisCoumarinCell cycleIC50Cell culturePharmacologyMicrotubuleBiochemistryCancer researchIn vitroCell biologyBiologyInternal medicineMedicineGeneticsOrganic chemistrySynthesis and biological activityQuinazolinone synthesis and applicationsFungal Plant Pathogen Control