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Ligand‐Free Suzuki–Miyaura Cross‐Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of their Optical and Electrochemical Performance

Valentina Pelliccioli, Giuseppe Dilauro, Sara Grecchi, Serena Arnaboldi, Claudia Graiff, Filippo Maria Perna, Paola Vitale, Emanuela Licandro, Alessandro Aliprandi, Silvia Cauteruccio, Vito Capriati

2020European Journal of Organic Chemistry31 citationsDOIOpen Access PDF

Abstract

We report that dihalogeno‐substituted benzodithiophenes ( BDTs ) undergo a smooth ligand‐free Suzuki–Miyaura cross‐coupling reaction, under air and moderate heating (60 °C), with aryl‐, alkenyl‐ and alkynyltrifluoroborate salts in a biodegradable choline chloride‐based eutectic mixture, thereby granting access to valuable π‐conjugated BDT compounds (up to 79 % yield), which are gaining great interest in the field of material sciences. The optical and electrochemical properties of these systems have been thoroughly investigated by means of absorption and cyclic voltammetry measurements. The first electrooligomerization study of a representative BDT derivative has also been undertaken.

Topics & Concepts

ChemistryCholine chlorideEutectic systemLigand (biochemistry)Cyclic voltammetryElectrochemistryCombinatorial chemistryArylDerivative (finance)Conjugated systemYield (engineering)Coupling reactionPhotochemistryPolymer chemistryOrganic chemistryCatalysisPhysical chemistryAlkylPolymerMaterials scienceElectrodeEconomicsBiochemistryFinancial economicsReceptorAlloyMetallurgyIonic liquids properties and applicationsConducting polymers and applicationsMolecular Junctions and Nanostructures
Ligand‐Free Suzuki–Miyaura Cross‐Coupling Reactions in Deep Eutectic Solvents: Synthesis of Benzodithiophene Derivatives and Study of their Optical and Electrochemical Performance | Litcius