Ppargc1a Controls Ciliated Cell Development by Regulating Prostaglandin Biosynthesis
Joseph M. Chambers, Amanda Addiego, Ana L. Flores‐Mireles, Rebecca A. Wingert
Abstract
) treatment in ppargc1a-deficient animals. Genetic disruption of ppargc1a specifically reduces expression of the prostanoid biosynthesis gene prostaglandin-endoperoxide synthase 1 (ptgs1), and suboptimal knockdown of both genes shows this synergistic effect. Furthermore, ptgs1 overexpression rescues ciliogenesis and renal MCCs in ppargc1a-deficient embryos. These findings position Ppargc1a as a key genetic regulator of prostaglandin signaling during ciliated cell ontogeny.
Topics & Concepts
BiosynthesisProstaglandinPPARGC1AChemistryCell biologyCellBiologyBioinformaticsBiochemistryGeneTranscription factorCoactivatorGenetic and Kidney Cyst DiseasesRenal and related cancersPancreatic function and diabetes