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PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer

Yizeng Fan, Yuzhao Wang, Weichao Dan, Yilei Zhang, Li Nie, Zhiqiang Ma, Yanxin Zhuang, Bo Liu, Mengxing Li, Tianjie Liu, Zixi Wang, Leihong Ye, Wei Yi, Yuzeshi Lei, Chendong Guo, Jun An, Chi Wang, Yulin Zhang, Jin Zeng, Wenyi Wei, Boyi Gan, Lei Li

2025Nature Cell Biology41 citationsDOI

Topics & Concepts

Protein arginine methyltransferase 5MethylationCell biologyArginineGPX4CancerChemistryCancer researchBiologyMethyltransferaseBiochemistryGeneEnzymeGeneticsGlutathioneAmino acidGlutathione peroxidaseCancer-related gene regulationEpigenetics and DNA MethylationRNA modifications and cancer
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer | Litcius