Bcl-2 Family Members and the Mitochondrial Import Machineries: The Roads to Death
Lisenn Lalier-Bretaudeau, François M. Vallette, Stéphen Manon
Abstract
The localization of Bcl-2 family members at the mitochondrial outer membrane (MOM) is a crucial step in the implementation of apoptosis. We review evidence showing the role of the components of the mitochondrial import machineries (translocase of the outer membrane (TOM) and the sorting and assembly machinery (SAM)) in the mitochondrial localization of Bcl-2 family members and how these machineries regulate the function of pro- and anti-apoptotic proteins in resting cells and in cells committed into apoptosis.
Topics & Concepts
Cell biologyTranslocaseMitochondrionBcl-2 familyApoptosisATP–ADP translocaseBacterial outer membraneTranslocase of the inner membraneTranslocase of the outer membraneFunction (biology)Mitochondrial apoptosis-induced channelBiologyMitochondrial carrierInner mitochondrial membraneProgrammed cell deathMitochondrial membrane transport proteinGeneticsGeneEscherichia coliChromosomal translocationCell death mechanisms and regulationMitochondrial Function and Pathologyinterferon and immune responses