Discovery of novel antagonists targeting the DNA binding domain of androgen receptor by integrated docking-based virtual screening and bioassays
Jinping Pang, Chao Shen, Wenfang Zhou, Yunxia Wang, Luhu Shan, Xin Chai, Ying Shao, Xueping Hu, Feng Zhu, Danyan Zhu, Li Xiao, Lei Xu, Xiaohong Xu, Dan Li, Tingjun Hou
Topics & Concepts
DU145Androgen receptorLNCaPVirtual screeningDocking (animal)Transcription factorDNA-binding domainChemistryAndrogen Receptor AntagonistsProstate cancerIn silicoCancer researchComputational biologyDrug discoveryBiologyGeneBiochemistryGeneticsCancerMedicineNursingProstate Cancer Treatment and ResearchProtein Degradation and InhibitorsEstrogen and related hormone effects