Characterization and Validation of Canine P-Glycoprotein-Deficient MDCK II Cell Lines for Efflux Substrate Screening
Dong Ye, Anna Harder, Zhizhou Fang, Manuel Weinheimer, Loïc Laplanche, Mario Mezler
Topics & Concepts
EffluxP-glycoproteinMultidrug resistance-associated protein 2TransporterTransfectionIn vivoATP-binding cassette transporterChemistryIn vitroCaco-2Abcg2BiologyPharmacologyBiochemistryMultiple drug resistanceGeneGeneticsAntibioticsDrug Transport and Resistance MechanismsGastroesophageal reflux and treatmentsBarrier Structure and Function Studies