Gold‐Catalyzed Alkoxy‐Carbonylation of Aryl and Vinyl Iodides
Vivek W. Bhoyare, Asish Bera, Vincent Gandon, Nitin T. Patil
Abstract
Herein, for the first time, we disclose the gold-catalyzed alkoxy-carbonylation of aryl and vinyl iodides utilizing ligand-enabled Au(I)/Au(III) redox catalysis. The present methodology is found to be general, efficient, employs mild reaction conditions and showcases a broad substrate scope even with structurally complex molecules. Density functional theory (DFT) calculations revealed mechanistic pathways distinct from those of conventional transition metal-catalyzed carbonylation reactions.
Topics & Concepts
CarbonylationCatalysisArylAlkoxy groupChemistryCombinatorial chemistryReductive eliminationLigand (biochemistry)Substrate (aquarium)Density functional theoryTransition metalMoleculeRedoxPhotochemistryOrganic chemistryComputational chemistryCarbon monoxideOceanographyGeologyReceptorAlkylBiochemistryCatalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions