Repopulated retinal microglia promote Müller glia reprogramming and preserve visual function in retinal degenerative mice
Xuan Cheng, Hui Gao, Zui Tao, Zhiyuan Yin, Zhe Cha, Xiaona Huang, Yikui Zhang, Yuxiao Zeng, Juncai He, Lingling Ge, A Luodan, Haiwei Xu, Guang-Hua Peng
Abstract
It suggested that Rep-MiG with the homeostasis characteristic stimulated the progenitor cell-like properties of MG, probably through regulating ECM remodeling, which protected photoreceptors and improved visual function of rd10 mice. It might be a potential protocol to reprogram MG and delay mammal retinal degeneration.
Topics & Concepts
MicrogliaRetinalRetinaRetinal regenerationCell biologyGliosisRetinal degenerationMuller gliaReprogrammingBiologyOuter nuclear layerElectroretinographyChemistryProgenitor cellNeuroscienceInflammationStem cellImmunologyCellBiochemistryRetinal Development and DisordersRetinal Diseases and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms