Azole-Resistant Alleles of <i>ERG11</i> in Candida glabrata Trigger Activation of the Pdr1 and Upc2A Transcription Factors
Bao Gia Vu, W. Scott Moye-Rowley
Abstract
activity can involve cellular effects beyond an alteration in this key azole target enzyme. Understanding the physiology linking ergosterol biosynthesis with Pdr1-mediated regulation of azole resistance is crucial for ensuring the continued efficacy of azole drugs against C. glabrata.
Topics & Concepts
AzoleCandida glabrataErgosterolCandida albicansBiologyMicrobiologyLanosterolFluconazoleMutantAlleleTranscription factorGeneFungal proteinDrug resistanceItraconazoleGeneticsYeastAmphotericin BTranscription (linguistics)Corpus albicansDemethylaseMutationAntifungal resistance and susceptibilityFungal and yeast genetics researchFungal Biology and Applications