Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
Katherine Tooley, Livnat Jerby, Giulia Escobar, S. Harsha Krovi, Davide Mangani, Gitanjali Dandekar, Hanning Cheng, Asaf Madi, Ella Goldschmidt, Conner Lambden, Rajesh K. Krishnan, Orit Rozenblatt–Rosen, Aviv Regev, Ana C. Anderson
Abstract
cell responses and is essential for effective anti-tumor immunity.
Topics & Concepts
StimulationCD28CD8Cytotoxic T cellImmunityCancerBiologyT cellCancer researchImmunologyImmune systemNeuroscienceGeneticsIn vitroCancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomicsCAR-T cell therapy research