Risk Factors for Being Seronegative following SARS-CoV-2 Infection in a Large Cohort of Health Care Workers in Denmark
Caroline Klint Johannesen, Omid Rezahosseini, Mikkel Gybel‐Brask, Jonas Henrik Kristensen, Rasmus Bo Hasselbalch, Mia Marie Pries‐Heje, Pernille Brok Nielsen, Andreas Dehlbæk Knudsen, Kamille Fogh, Jakob Norsk, Ove Andersen, Claus Antonio Juul Jensen, Christian Torp‐Pedersen, Jørgen Rungby, Sisse B. Ditlev, Ida Hageman, Rasmus Møgelvang, Ram Benny Dessau, Erik Sørensen, Lene Holm Harritshøj, Fredrik Folke, Curt Sten, Maria Elizabeth Engel Møller, Frederik Neess Engsig, Henrik Ullum, Charlotte Sværke Jørgensen, Sisse Rye Ostrowski, Henning Bundgaard, Kasper Iversen, Thea Kølsen Fischer, Susanne Dam Nielsen
Abstract
Most individuals seroconvert after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but negative serology is observed in 1 to 9%. We found that asymptomatic or mild infection as well as a BMI above 30 were associated with being seronegative. Since the presence of antibodies against SARS-CoV-2 reduces the risk of reinfection, efforts to protect HCW with risk factors for being seronegative may be needed in future COVID-19 surges.