Editorial: Reactive oxygen species (ROS) signaling during cytoskeleton dynamics
Lia S. Nakao, Michael F. Olson, José Pablo Vázquez‐Medina, Alejandra Valdivia
Abstract
First, in the article "Nox1-based NADPH oxidase regulates the Par protein complex activity to 34 control cell polarization", the authors described new mechanism by which Nox-1-derived ROS 35 regulate directional cell migration. Here, cells lacking Nox1 showed reduced migration and failed to a single lamellipodium at the leading edge of cells, while the addition exogenous H2O2 or 37 Nox1 re-expression rescued this phenotype. Mechanistically, Nox1 deficiency induces PP2A 38 mislocation and inactivation, leading to increased phosphorylation and hyperactivation of the Par3, 39 aPKC, Tiam, and Rac1 polarity complex. Moreover, the authors evaluated the physiological 40 relevance of this signaling pathway using a murine model of femoral artery wire injury to generate 41 neointimal hyperplasia followed by histological analysis. Their results suggest that PP2A and aPKC 42 might contribute to reducing neointima formation observed in Nox1 We thank all the authors, editors, and reviewers who contributed to this Research Topic.