One-step synthesis of azepino[3,4-<i>b</i>]indoles by cooperative aza-[4 + 3] cycloaddition from readily available feedstocks
Jin‐Tian Ma, Ting Chen, Xiang‐Long Chen, You Zhou, Zhi‐Cheng Yu, Shi‐Yi Zhuang, Maierhaba Alimu, Yan‐Dong Wu, Jia‐Chen Xiang, An‐Xin Wu
Abstract
We demonstrate the feasibility of obtaining azepino[3,4- b ]indoles by one-step synthesis from a four-component reaction system comprising readily available starting materials. This transformation affords a diverse range of azepino[3,4- b ]indoles in a highly efficient manner.
Topics & Concepts
ChemistryCycloadditionCombinatorial chemistryTransformation (genetics)Component (thermodynamics)Organic chemistryCatalysisBiochemistryThermodynamicsPhysicsGeneAsymmetric Synthesis and CatalysisChemical synthesis and alkaloidsCyclopropane Reaction Mechanisms