Continuous-flow processes for the <i>S</i>-alkynylation of cysteine-containing peptides and thioglycosides under catalyst-free, oxidant-free and mild conditions
Long‐Zhou Qin, Xin Yuan, Jie Liu, Meng‐Yu Wu, Qi Sun, Xiu Duan, Xinpeng Zhang, Jiang‐Kai Qiu, Kai Guo
Abstract
Selective S -alkynylation of cysteine-containing peptides and 1-thioglycoside residues was developed using continuous flow.
Topics & Concepts
AlkynylationChemistryCatalysisCysteineFree flowContinuous flowCombinatorial chemistryOrganic chemistryBiochemical engineeringPhysicsEngineeringEnzymeMechanicsChemical Synthesis and AnalysisSulfur-Based Synthesis TechniquesCarbohydrate Chemistry and Synthesis