Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics
Daniel Haensel, Suoqin Jin, Peng Sun, Rachel Cinco, Morgan Dragan, Quy Nguyen, Zixuan Cang, Yanwen Gong, Remy Vu, Adam L. MacLean, Kai Kessenbrock, Enrico Gratton, Qing Nie, Xing Dai
Abstract
state to early-response state, proliferate at the juncture of these two states, or become growth arrested before differentiating into spinous cells. Wound healing induces plasticity manifested by dynamic basal-spinous interconversions at multiple basal transcriptional states. Our study provides a systematic view of epidermal cellular dynamics, supporting a revised "hierarchical-lineage" model of homeostasis.
Topics & Concepts
Wound healingHomeostasisCell biologyCellBasal (medicine)TranscriptomeBiologyEpidermis (zoology)AnatomyImmunologyGene expressionEndocrinologyBiochemistryGeneInsulinImmunotherapy and Immune ResponsesSingle-cell and spatial transcriptomicsCell Adhesion Molecules Research