Attenuated diphtheria toxin mediates siRNA delivery
Amy E. Arnold, Laura J. Smith, Greg L. Beilhartz, Laura C. Bahlmann, Emma Jameson, Roman A. Melnyk, Molly S. Shoichet
Abstract
resulted in significant cell death. This is the first example of diphtheria toxin being used to deliver siRNAs, and the first time a toxin-based siRNA delivery strategy has been shown to induce relevant genotypic and phenotypic effects in cancer cells.
Topics & Concepts
Diphtheria toxinDiphtheriaToxinSmall interfering RNAVirologyImmunizationCorynebacterium diphtheriaeBiologyMicrobiologyMedicineImmunologyVaccinationTransfectionGeneticsCell cultureImmune systemRNA Interference and Gene DeliveryVirus-based gene therapy researchBacteriophages and microbial interactions