PD-1 expression contributes to functional impairment of NK cells in patients with B-CLL
Farhat Mustafa, Wayne Croft, Helen Parry, Kriti Verma, Francesca Kinsella, XU Jin-song, David Bone, Tina McSkeane, Shankara Paneesha, Guy Pratt, Paul Moss, Jianmin Zuo
Abstract
B cell chronic lymphocytic leukemia (B-CLL) is a common leukemia subtype [ 1 ] and compromised immune function is a major clinical problem leading to increased mortality among patients [ 2 ].
Topics & Concepts
Chronic lymphocytic leukemiaImmunologyImmune systemNKG2DBiologyTIGITDegranulationCancer researchLeukemiaReceptorCytotoxic T cellT cellIn vitroBiochemistryChronic Lymphocytic Leukemia ResearchImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers