Electrophysiological and pharmacological characterization of spreading depolarization in the adult zebrafish tectum
Haruhi Terai, Mayeso Naomi Victoria Gwedela, Koichi Kawakami, Hidenori Aizawa
Abstract
Previous studies have implicated spreading depolarization (SD) in stroke and migraine. Here, we demonstrate SD, for the first time, in the adult zebrafish tectum showing waveform kinetics, c-fos expression, and attenuation by N-methyl-d-aspartate glutamate receptor blocker as observed in the rodent cortex. Since the zebrafish is an animal model amenable to genetic manipulation and chemical screening, this result could pave the way to novel diagnostic and therapeutic methods applicable to SD-associated neurological disorders.
Topics & Concepts
ElectrophysiologyNeuroscienceDepolarizationZebrafishOptic tectumTectumBiologyCommunicationPsychologyCentral nervous systemBiophysicsMidbrainBiochemistryGenePhotoreceptor and optogenetics researchCircadian rhythm and melatoninNeuroscience of respiration and sleep