Discovery of novel isatin-based thiosemicarbazones: synthesis, antibacterial, antifungal, and antimycobacterial screening
Shohreh Mohebbi, Maryam Hassan, Ramtin Ghaffari, Soroush Sardari, YektaFarmahini Farahani
Abstract
BACKGROUND AND PURPOSE: . EXPERIMENTAL APPROACH: ) were prepared by a condensation reaction between thiosemicarbazide and substituted N-aryl isatins leading to the desired thiosemicarbazones with exquisite purity. FINDINGS / RESULTS: showed the best activities against M. bovis BCG. CONCLUSION AND IMPLICATIONS: To sum up, amongst the 10 synthesized compounds, fluorinated derivatives exhibited remarkable activities against both gram negative strains and candida albicans microorganism. Therefore, they should be considered as a clue for further modifications in next investigations. Furthermore, inserting a small/medium size halogen atom with electron-withdrawing and lipophilic properties increases anti- salmonella activity of these compounds and moreover 2-halogenated semithiocarbazones presented promising antimycobacterial activity.