Lef1 restricts ectopic crypt formation and tumor cell growth in intestinal adenomas
Sarika Heino, Shentong Fang, Marianne Lähde, Jenny Högström, Sina Nassiri, Andrew D. Campbell, Dustin J. Flanagan, Alexander Raven, Michael C. Hodder, Nadia Nasreddin, Hai‐Hui Xue, Mauro Delorenzi, Simon J. Leedham, Tatiana V. Petrova, Owen J. Sansom, Kari Alitalo
Abstract
expression suppresses intestinal tumorigenesis by restricting adenoma cell dedifferentiation to a crypt-progenitor phenotype and by reducing the formation of cancer stem cell niches.
Topics & Concepts
CryptSomatic cellEctopic expressionCancer researchBiologyCell biologyGeneticsCell cultureEndocrinologyGeneCholangiocarcinoma and Gallbladder Cancer StudiesCancer-related molecular mechanisms researchCancer Cells and Metastasis