Daptomycin Resistance in Enterococcus faecium Can Be Delayed by Disruption of the LiaFSR Stress Response Pathway
Amy G. Prater, Heer H. Mehta, Kathryn Beabout, Adeline Supandy, William R. Miller, Truc T. Tran, César A. Arias, Yousif Shamoo
Abstract
response regulator gene deletion evolved DAP resistance. We found that knocking out LiaFSR signaling significantly delayed the onset of resistance, but resistance could emerge eventually through various alternate mechanisms that were influenced by the environment.
Topics & Concepts
DaptomycinEnterococcus faeciumEnterococcusMedicineMicrobiologyAntibacterial agentAntibioticsPharmacologyBiologyBacteriaStaphylococcus aureusVancomycinGeneticsAntimicrobial Resistance in StaphylococcusBacterial Identification and Susceptibility TestingPlant-Microbe Interactions and Immunity