Cell-Surface-Anchored DNA Sensors for Simultaneously Monitoring Extracellular Sodium and Potassium Levels
Zhiwei Deng, Peiru Gao, Hui Liu, Yao He, Shian Zhong, Yanjing Yang
Abstract
The K+ and Na+ levels in cells have a synergistic effect on many biological processes (BPs); therefore, the simultaneous detection of them is important. Here, we propose a novel Y-shaped DNA sensor for simultaneous monitoring of Na+ and K+ in extracellular microenvironments. The designed sensor contributed to the selective response to the above two ions. In addition, it performed the imaging of the above two ions on the cell surface in a real-time, on-site manner, which would shed more light on the association of the Na+/K+ content with regulatory BPs. We believe that this new strategy will be a promising tool to investigate the synergy of Na+/K+ in regulating different BPs.
Topics & Concepts
ChemistryExtracellularPotassiumDNASodiumCellBiophysicsIonBiochemistryOrganic chemistryBiologyAdvanced biosensing and bioanalysis techniquesAnalytical Chemistry and SensorsElectrochemical Analysis and Applications