Structural and functional analyses of a GPCR-inhibited ion channel TRPM3
Chen Zhao, Roderick MacKinnon
Abstract
occupancy; however, in all cases, Gβγ appears loosely attached to TRPM3. The IC50 in electrophysiology experiments raises the possibility that additional unknown factors may stabilize the TRPM3-Gβγ complex.
Topics & Concepts
G protein-coupled receptorIon channelElectrophysiologyChemistryBiophysicsReceptorCell biologyBiochemistryBiologyNeuroscienceIon Channels and ReceptorsIon channel regulation and functionPlant Stress Responses and Tolerance