Rhodium-catalyzed multiple C–H activation/highly<i>meta</i>-selective C–H amination between amidines and alkynes
Fen Xu, Yuanyuan Song, Wenjing Zhu, Chun‐Sen Liu, Ya-Zhou Lu, Miao Du
Abstract
A tandem process of multiple C-H activation and intermolecular highly meta-selective C-H amination between amidines and alkynes has been developed. Mechanistic studies demonstrate that the reaction is proposed to proceed through two different Rh(i)-Rh(iii) catalytic cycles, wherein Rhodium-complex I and Rhodacycle intermediate II were isolated for the first time.
Topics & Concepts
RhodiumCatalysisAminationChemistryMedicinal chemistryCombinatorial chemistryOrganic chemistrySynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques