Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function
Bridie J. Goggins, Kyra Minahan, Simonne Sherwin, Wai Sinn Soh, Jennifer Pryor, Jessica Bruce, Gang Liu, Andrea Mathe, Darryl A. Knight, Jay C. Horvat, Marjorie M. Walker, Simon Keely
Abstract
HIF-1 plays an important role in epithelial restitution, selectively inducing integrins α6 and α2 to promote migration and proliferation, respectively. HIF-stabilizing prolyl-hydroxylase inhibitors accelerate intestinal mucosal healing by inducing epithelial integrin expression.
Topics & Concepts
IntegrinCell biologyFunction (biology)ChemistryCancer researchBiologyReceptorBiochemistryCancer, Hypoxia, and MetabolismCancer Research and TreatmentsMetabolism, Diabetes, and Cancer