Recent advances and strategies in BET bromodomain inhibition for drug discovery
Ping-Fan Zhang, Yi-Sheng Li, Cheng Wang, Yuhui Gao, Jingying Liu, Hong-En Zhang, Lei Shi, Li‐Ping Sun
Topics & Concepts
BromodomainEpigeneticsDrug discoveryChemistryComputational biologyPharmacologyFunction (biology)BRD4Drug developmentDrug candidateDrugBET inhibitorCancerSmall moleculeBioinformaticsDruggabilityStructure–activity relationshipProtein Degradation and InhibitorsUbiquitin and proteasome pathwaysMultiple Myeloma Research and Treatments