m<sup>6</sup>A RNA methylation drives kidney fibrosis by upregulating β-catenin signaling
Yinyi Long, Dongyan Song, Liuyan Xiao, Yadie Xiang, Dier Li, Xiaoli Sun, Xue Hong, Fan Fan Hou, Haiyan Fu, Youhua Liu
Abstract
A modification of β-catenin mRNA, leading to its stabilization and its downstream profibrotic genes expression. Our findings suggest that targeting METTL3/IGF2BP3/β-catenin pathway may be a novel strategy for the treatment of fibrotic CKD.
Topics & Concepts
MethylationRNACancer researchKidneyDNA methylationCateninChemistryMolecular biologyMedicineBiologySignal transductionCell biologyInternal medicineWnt signaling pathwayBiochemistryGene expressionDNAGeneRNA modifications and cancerCancer-related gene regulation