New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota

Heping Shen, Qiaobing Guan, Xiaoling Zhang, Chao Yuan, Zhengye Tan, Liping Zhai, Yanan Hao, Yanling Gu, Chenyang Han

2020Progress in Neuro-Psychopharmacology and Biological Psychiatry197 citationsDOI

Topics & Concepts

NeuroinflammationGut floraMicrogliaHippocampusGut–brain axisImmunologyInflammasomeTransplantationCognitive declineGenetically modified mouseMedicineInflammationBiologyDiseasePathologyInternal medicineTransgeneDementiaGeneBiochemistryGut microbiota and healthTryptophan and brain disordersDiet and metabolism studies