Cinchona Alkaloid Derived Iodide Catalyzed Enantioselective Oxidative α-Amination of Carbonyl Compounds toward the Construction of Spiroindolyloxindole
Dangui Wang, Wentao Zhang, Xunbo Lu, Hongwei Zhou, Fangrui Zhong
Abstract
Novel cinchona alkaloid derived iodide catalysts were developed for the enantioselective oxidative α-amination of 2-oxindoles, providing various functionalized spiropyrrolidine oxindoles in high yields and with good enantioselectivities. This iodide/ROOH catalytic system features a one-step synthesis of a catalyst with multiple functionalities, ease of operation, and good scalability, thereby enriching the repertoire of iodide catalysis for enantioselective oxidative coupling reactions.
Topics & Concepts
Enantioselective synthesisChemistryCinchonaAminationIodideCatalysisOrganic chemistryOxidative phosphorylationCombinatorial chemistryAlkaloidOxidative coupling of methaneBiochemistryOxidative Organic Chemistry ReactionsAlkaloids: synthesis and pharmacologySynthesis and Catalytic Reactions