Tofacitinib-induced remission in refractory adult-onset Still’s disease complicated by macrophage activation syndrome
Manabu Honda, Mayuko Moriyama, Masahiro Kondo, Shunichi Kumakura, Yohko Murakawa
Abstract
Adult-onset Still’s disease (AOSD) is rarely complicated by macrophage activation syndrome (MAS), which is also called secondary haemophagocytic lymphohistiocytosis (HLH) (1, 2). MAS is a life-thre...
Topics & Concepts
Macrophage activation syndromeMedicineAdult-onset Still's diseaseRefractory (planetary science)Hemophagocytic lymphohistiocytosisTofacitinibDiseaseImmunologyMacrophagePediatricsInternal medicineBiochemistryIn vitroAstrobiologyPhysicsChemistryRheumatoid arthritisAutoimmune and Inflammatory Disorders ResearchImmune Cell Function and InteractionAdolescent and Pediatric Healthcare