MOLECULAR MODELING, ADMET PREDICTION, SYNTHESIS AND THE CYTOTOXIC ACTIVITY FROM THE NOVEL N-(4-tert-BUTYLPHENYLCARBAMOYL)BENZAMIDE AGAINST HELA
Bambang Purwanto, Siswandono, Dini Kesuma, Tri Widiandani, Imam Siswanto
Abstract
Efforts to develop urea derivatives as anticancer agents thrive due to their proven anticancer activities. N-(4-tertbutylphenylcarbamoyl)benzamide was synthesized by Schotten Baumann reaction, rendering 59%. To determine the purity, a thin-layer chromatography method in 3 different mobile phases was adopted, indicating a stain with distinguishing Rf. Structure identification indicating the compound was N-(4-tert-butylphenylcarbamoyl)benzamide.
Topics & Concepts
BenzamideHeLaProtein Data Bank (RCSB PDB)ChemistryIC50Docking (animal)Cytotoxic T cellCytotoxicityStereochemistryIn vitroPharmacologyBiochemistryBiologyMedicineNursingSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Reactions of Organic Compounds