Carbamoyl Fluoride-Enabled Enantioselective Ni-Catalyzed Carbocarbamoylation of Unactivated Alkenes
Yue Li, Feng‐Ping Zhang, Rong-Hua Wang, Shaolong Qi, Yu‐Xin Luan, Mengchun Ye
Abstract
A carbamoyl fluoride-enabled enantioselective Ni-catalyzed carbocarbamoylation of unactivated alkenes was developed, providing a broad range of chiral γ-lactams bearing an all-carbon quaternary center in 45-96% yield and 38-97% ee.
Topics & Concepts
Enantioselective synthesisChemistryFluorideCatalysisYield (engineering)Organic chemistryQuaternary carbonCombinatorial chemistryMedicinal chemistryInorganic chemistryMaterials scienceMetallurgyFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions