Role of STIM1 in stretch-induced signaling in human airway smooth muscle
Yang Yao, Mengning Zheng, Niyati A. Borkar, Michael A. Thompson, Emily Zhang, Maunick Lefin Koloko Ngassie, Shengyu Wang, Christina M. Pabelick, Elizabeth R. Vogel, Y. S. Prakash
2024American Journal of Physiology-Lung Cellular and Molecular Physiology12 citationsDOIOpen Access PDF
Abstract
Mechanical forces on the airway can contribute to altered contractility and remodeling in airway diseases, but the mechanisms are not clearly understood. Using human airway smooth muscle cells exposed to cyclic forces with static stretch to mimic breathing and static pressure, we found that the effects of stretch are mediated through STIM1, resulting in the activation of multiple pathways, including Piezo channels and the inflammasome, with potential downstream influences on contractility and remodeling.
Topics & Concepts
AirwayAnatomyCell biologyNeuroscienceBiologyMedicineAnesthesiaIon Channels and ReceptorsLaser Applications in Dentistry and Medicine