Intersections of endocrine pathways and the epithelial mesenchymal transition in endometrial cancer
Julia Gelissen, Gloria S. Huang
Abstract
The epithelial mesenchymal transition (EMT) is the process by which cancer cells of epithelial origin, including endometrial cancer, acquire a mesenchymal phenotype with enhanced migratory and invasive capacity, to facilitate metastasis. The regulation of EMT is tissue-specific, and in endometrial cancer, endocrine signaling pathways serve as critical regulators of EMT. The intersections of endocrine signaling and EMT highlight potential avenues for therapeutic intervention to target cancer metastasis with the aim of reduced mortality.
Topics & Concepts
Epithelial–mesenchymal transitionEndometrial cancerMetastasisEndocrine systemCancer researchMesenchymal stem cellCancerSignal transductionPhenotypeBiologyMedicineOncologyInternal medicinePathologyCell biologyHormoneGeneBiochemistryCancer Cells and MetastasisMetastasis and carcinoma case studiesCancer-related molecular mechanisms research