Targeting the HIF-1α-IGFBP2 axis therapeutically reduces IGF1-AKT signaling and blocks the growth and metastasis of relapsed anaplastic Wilms tumor
Yan Liu, Marie Nelson, Christopher M. Bailey, Peng Zhang, Pan Zheng, Jeffrey S. Dome, Yang Liu, Yin Wang
Topics & Concepts
MetastasisProtein kinase BCancer researchBiologyWilms' tumorHypoxia-inducible factorsGrowth factorSignal transductionTumor progressionCancerInternal medicineReceptorMedicineCell biologyGeneticsGeneBiochemistryRenal and related cancersGrowth Hormone and Insulin-like Growth FactorsCancer, Hypoxia, and Metabolism