A metal-organic framework@hydrogen-bond framework as a matrix for MALDI-TOF-MS analysis of small molecules
Shi‐Jun Yin, Guo-Can Zheng, Xin Yi, Guangping Lv, Feng Yang
Abstract
A novel MOF@HOF composite that can serve as a matrix for analysis of small molecules by MALDI-TOF-MS was fabricated through a simple solvothermal method. Taking falvonoids as an example, this composite/matrix presents high desorption/ionization efficiency, low background interference, high salt tolerance, and satisfactory signal reproducibility for MALDI-TOF-MS analysis.
Topics & Concepts
Small moleculeMatrix (chemical analysis)Matrix-assisted laser desorption/ionizationDesorptionComposite numberMoleculeReproducibilityMass spectrometryMetal-organic frameworkOrganic moleculesHydrogen bondMALDI imagingChemistryMaterials scienceChromatographyOrganic chemistryAdsorptionComposite materialBiochemistryMass Spectrometry Techniques and ApplicationsLuminescence and Fluorescent MaterialsAnalytical chemistry methods development