Engineering of Portable Smartphone Integrated with Liposome‐Encapsulated Curcumin for Onsite Visual Ratiometric Fluorescence Imaging of Hypochlorite
Yizhong Shen, Chunlei Zhu, Yunlong Wei, Huanhuan Chen, Zeyu Wu, Yingwang Ye, Deman Han
Abstract
Abstract Precisely onsite monitoring of hypochlorite (ClO − ) is of great significance to guide its rational use, reducing/avoiding its potential threat toward food safety and human health. Considering ClO − could quench fluorescence of curcumin (CCM) by oxidizing the o ‐methoxyphenol of CCM into benzoquinone, a portable ratiometric fluorescence sensor integrated with smartphone was designed for realizing the visual point‐of‐care testing (POCT) of ClO − . The amphiphilic phospholipid polymer was used as carrier to wrap curcumin, forming a novel liposome‐encapsulated CCM, which provided a scaffold to bind with [Ru(bpy) 3 ] 2+ through electrostatic interaction, thus assembling [Ru(bpy) 3 ] 2+ ‐functionalized liposome‐encapsulated CCM ([Ru(bpy) 3 ] 2+ @CCM‐NPs). Further integrated with smartphone, visual imaging of [Ru(bpy) 3 ] 2+ @CCM‐NPs could be achieved and the accurate onsite detection of ClO − could be realized with a detection limit of 66.31 nM and a linear range of 0.2210 to 80.0 μM. In addition, the sensor could monitor ClO − in real samples with an onsite detection time of ∼154.0 s.