Orexin-A protects against cerebral ischemia-reperfusion injury by inhibiting excessive autophagy through OX1R-mediated MAPK/ERK/mTOR pathway
Dandan Xu, Tingting Kong, Shengnan Zhang, Baohua Cheng, Jing Chen, Chunmei Wang
Topics & Concepts
NeuroprotectionAutophagyPI3K/AKT/mTOR pathwayMAPK/ERK pathwayTUNEL assayApoptosisBrain ischemiaReperfusion injuryPharmacologyProgrammed cell deathIschemiaViability assayCell biologyBiologyChemistryMedicineSignal transductionInternal medicineBiochemistrySleep and Wakefulness ResearchAutophagy in Disease and TherapyCannabis and Cannabinoid Research