Interdependent allosteric free fatty acid receptor 2 modulators synergistically induce functional selective activation and desensitization in neutrophils
Simon Lind, André Holdfeldt, Jonas Mårtensson, Martina Sundqvist, Terry Kenakin, Lena Björkman, Huamei Forsman, Cláes Dahlgren
Topics & Concepts
Allosteric regulationChemistryAgonistNADPH oxidaseHomologous desensitizationFunctional selectivitySuperoxideBiochemistryCell biologyAllosteric modulatorReceptorEndogenous agonistBiophysicsPharmacologyBiologyReactive oxygen speciesEnzymeDopamine receptor D1Receptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Receptor Mechanisms and Effects