RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis
Xinjun Ji, Anupama Jha, Jesse Humenik, Louis R. Ghanem, Andrew Kromer, Christopher Duncan-Lewis, Elizabeth A. Traxler, Mitchell J. Weiss, Yoseph Barash, Stephen A. Liebhaber
Abstract
analyses of primary erythroid progenitors selectively depleted of these two RNA-binding proteins revealed that they mediate a combination of overlapping and isoform-specific impacts on hematopoietic lineage transcriptome, impacting both mRNA representation and exon splicing. These data lead us to conclude that PCBP1 and PCBP2 mediate functions critical to differentiation of the erythroid lineage.
Topics & Concepts
BiologyRNA-binding proteinAlternative splicingMolecular biologyCell biologyHaematopoiesisErythropoiesisRNAExonGeneGeneticsStem cellInternal medicineAnemiaMedicineRNA Research and SplicingErythrocyte Function and PathophysiologyRNA modifications and cancer